Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension Running title: Ranchoux et al.; EndoMT in pulmonary hypertension
نویسندگان
چکیده
Univ. Paris-Sud, Faculté de médecine, Kremlin-Bicêtre, France; AP-HP, DHU TORINO, Centre de Référence de l’Hypertension Pulmonaire Sévère, Service de Pneumologie et Réanimation Respiratoire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; INSERM UMR-S 999, Labex LERMIT, Hypertension Artérielle Pulmonaire: Physiopathologie et Innovation Thérapeutique, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France; INRA U1196, Génomique et Physiologie de la Lactation – Plateau de Microscopie Electronique à Transmission, Jouy-en-Josas, France; Service de Chirurgie Thoracique, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France; Service d’Anatomie Pathologique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France; Dept of Pulmonary Medicine, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; INSERM UMR 1064-Center for Research in Transplantation and ImmunologyITUN et Transgenic Rats and Immunophenomic Platform, Nantes, France; INSERM U955, Dépt de Physiologie and Service de Cardiologie, Hôpital Henri Mondor, AP-HP, Université Paris-Est Créteil (UPEC), Créteil, France *contributed equally
منابع مشابه
Endothelial-to-mesenchymal transition in pulmonary hypertension.
BACKGROUND The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. METHODS AND RESULTS In situ evidence of EndoMT in hu...
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